5 MeO DMT is a psychedelic of the tryptamine class. It is found in a wide variety of plant species, and at least one psychoactive toad species, the Sonora Desert toad. Like its close relatives DMT and bufotenin, it has been used as an entheogen in South America
5-MeO-DMT is a research chemical psychedelic of the tryptamine class, four to six times more powerful than its better-known cousin, DMT (N,N-dimethyltryptamine). It can be found in a wide variety of trees and shrubs, often alongside DMT and bufotenine (5-HO-DMT).
In Central and South America, some of the best known 5-MeO-DMT sources are Anadenanthera peregrina (yopo or cohoba) and Virola theiodora—both of which are traditionally harvested to make psychoactive snuff. It’s also found in the milky white venom of the Colorado River Toad (Bufo alvarius/Incilius alvarius) native to the southwestern United States and northwestern Mexico.
In keeping with its ceremonial use among indigenous Amazonians, 5-MeO shows great promise in the treatment of certain medical conditions. Many people also find its effects to be personally useful or even life changing.
Vaporizing or smoking 5-MeO powder is probably the most common route of administration. The next common is snorting or insufflation.
Effects from vaporizing or smoking 5-MeO are usually felt within the first 30 seconds, peaking from 1-15 minutes and lasting for up to half an hour. A threshold dose is around 1-2 mg, while a moderate-to-strong dose is 5-10 mg.
Insufflated, it may take up to five minutes to feel the effects, despite the higher dose ranges involved (threshold: 3-5 mg; moderate: 8-15 mg). Effects tend to peak after 10-30 minutes and subside from around 30-45.
5-MeO oral doses for swallowing are higher, with generally unreliable results. Other less common routes of administration include sublingual (under the tongue) and injection.
5 Meo DMT
The Church of the Tree of Life, founded in California in 1971 by John Mann but now defunct, declared the use of 5-MeO to be a sacrament. From approximately 1971 to the late 1980s, 5-MeO was discreetly available to its members. Between 1970 and 1990 smoking of 5-MeO on parsley was probably one of the two most common forms of ingestion in the United States.